Gastrointestinal Lesions in Rheumatoid Arthritis Hiroyuki Kobayashi 1 , Tadahiko Fuchigami 1 1Institute of Gastroenterology, Matsuyama Red Cross Hospital Keyword: 慢性関節リウマチ , NSAIDs潰瘍 , NSAIDs腸炎 , 続発性消化管アミロイドーシス , 血管炎 pp.521-528
Published Date 2003/4/24
DOI https://doi.org/10.11477/mf.1403100909
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 Rheumatoid Arthritis (RA) is known to give rise to various types of gastrointestinal complications such as those due to vasculitis, secondary amyloidosis, therapeutic drugs including nonsteroidal antiinflammatory drugs (NSAIDs), and so on. NSAIDs cause mainly gastric mucosal injury (ulcer). Unlike usual ulcers, these ulcers are often asymptomatic, predominant in the antrum, multiple, deep and accompanied with edema. Amyloidosis is a serious complication affecting the prognosis of patients of RA. Its clinical features are similar to amyloidosis accompanying other diseases. Biopsy from duodenal mucosa is useful for early diagnosis of amyloidosis. Intestinal lesions in RA are thought to be involved in ischemia such as that induced by vasculitis, NSAIDs, and others. These intestinal lesions show an extremely wide variety, and the causes have many points in common with each other. Therefore, it is speculated that intestinal lesions in RA might be formed as a result of a correlation of these factors, i. e. vasculits, drugs, etc.

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