The Sign of Leser-Trélat Keisuke Ito 1 , Yoshifumi Yokoyama 1 , Makoto Itoh 1 1Department of Internal Medicine and Bioregulation, Graduate School of Medical Sciences, Nagoya City University Keyword: Leser-Trélat徴候 , 消化管悪性腫瘍 , 直腸癌 , 脂漏性角化症 pp.495-499
Published Date 2003/4/24
DOI https://doi.org/10.11477/mf.1403100905
  • Abstract
  • Look Inside
  • Reference
  • Cited by

 The sign of Leser-Trélat is a skin symptom which is definitely related to visceral malignancy (Dermadrome). When seborrheic keratoses suddenly appears and rapidly increases in number and size (during a period of 6 months), it is a sure sign a visceral malignancy. In our case, a 71-year-old female, seborrheic keratoses suddenly appeared and rapidly increased on her skin, nine months before a rectal cancer was detected. We recognized the skin lesions as the sign of Leser-Trélat.

 We also investigated the types of malignancy with the Leser-Trélat sign among 115 reported cases in Japan (including our case). There were 58 cases of gastric cancer (50.4%) and twelve cases of colorectal cancer (10.4%). Most of the cases were malignancy of the gastrointestine. Patients with seborrheic keratoses are often encountered, but the sudden appearance and rapid increase of the eruption is the important sign that indicates intestinal malignancy. Careful observation of the sudden opread of seborrheic keratoses is one of the ways to detect malignancy in its earlier stage.

Copyright © 2003, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院