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Well-differentiated Type Adenocarcinomas of Gastric Mucin Phenotype Transform into Intestinal Type Carcinomas Gen Watanabe 1 , Hidenobu Watanabe 1 , Yoichi Ajioka 1 , Hidefumi Shiroshita 1 , Ken Nishikura 1 1Department of Molecular Genetics, Division of Molecular and Diagnostic Pathology, Niigata University, Graduate School of Medical and Dental Sciences Keyword: 胃の高分化型腺癌 , 粘液形質 , 胃型 , 胃腸型 , 小腸型 pp.693-700
Published Date 2003/4/25
DOI https://doi.org/10.11477/mf.1403100862
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 We studied the frequency of well-differentiated type adenocarcinomas with gastric, gastrointestinal, and small-intestinal phenotypes in early gastric carcinomas as well as the change in mucin phenotype from one to another, using CD10, MUC2, MUC5AC, HGM, and MUC6 immunostains. 25% of the cases we studied were of gastric type (with 5% or more gastric type mucin), of 35% gastrointestinal type (with 5% or more MUC2 mucin), and of 40% small-intestinal type (with CD10 positive cells, irrespective of their number) (Table 4). All of the gastric-type cancers had MUC2 positive cells of less than 5%, and 63% of small-intestinal type-cancers had cells positive for gastric type mucin. It is suggested that gastric-type cancer may transform into gastrointestinal-type and then into small-intestinal-type one as seen in non-neoplastic mucosa.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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