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Well-differentiated Tubular Adenocarcinoma with a Predominantly Intestinal Phenotype Pattern in the Gastric Antrum of a Helicobacter pylori-negative Patient, Report of a Case Fumito Tsuruta 1,2 , Koji Kawai 3 , Tomonari Amano 4 , Daisuke Hattori 1 , Tatsuhiko Cho 1 , Miki Yoshida 1 , Ayako Misawa 1 , Yuji Aoyagi 1 1Department of Gastroenterology, Tokyo-Kita Medical Center, Tokyo 2Koshigaya clinic of Gastrointestinal Internal Medicine and Dermatology, Koshigaya, Japan 3Department of Internal Medicine, Ito Municipal Hospital, Ito, Japan 4Department of Diagnostic Pathology, Tokyo-Kita Medical Center, Tokyo Keyword: Helicobacter pylori未感染 , 分化型胃癌 , 腸型形質 , 胆汁酸 pp.949-958
Published Date 2016/6/25
DOI https://doi.org/10.11477/mf.1403200671
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 A woman in her thirties was admitted to our hospital for examination of abnormal gastric antral findings detected by screening EGD(esophagogastroduodenoscopy). Both radiographic studies and EGD revealed an elevated lesion in the gastric antrum that was Group4 histologically by endoscopic biopsy. There was no histological evidence of atrophy or gastritis of the background mucosa and no histological gastritis according to Updated Sydney system. The serum Helicobacter pylori(H. pylori)antibody titer and urea breath test were negative. We performed endoscopic submucosal dissection of this lesion with a diagnosis of early gastric cancer(IIa+IIc). Examination of the resected specimen revealed at the lesion was a well-differentiated tubular adenocarcinoma with predominantly intestinal histology. It is considered to be extremely rare for differentiated gastric cancer of the intestinal type to occur in the pyloric gland area of a H. pylori negative patient. Accordingly we reported this case with discussion of the literature.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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