Usefulness and Pespective of Endocytoscopy on Colorectal Lesions Keita Sasajima 1 , Shin-ei Kudo 1 , Hiroshi Kashida 1 , Haruhiro Inoue 1 , Eiji Hidaka 1 , Yasutoshi Kobayashi 1 , Yui Kudo 1 , Nobunao Ikehara 1 , Junichi Tanaka 1 , Shigeharu Hamatani 2 , Akira Shiokawa 2 1Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan 2Department of Clinical Pathology, Showa University Northern Yokohama Hospital, Yokohama, Japan Keyword: endocytoscopy , in vivo , probe-type , integrated-type , optical biopsy pp.1801-1810
Published Date 2006/12/25
DOI https://doi.org/10.11477/mf.1403100820
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 The subjects were 113 consecutive patients who underwent a complete colonic examination. Endocytoscopic examination was performed on 75 localized colorectal lesions including normal mucosa with a probe-type endocytoscope. The design was prospective. A pathologist, who was blinded to the conventional colonoscopic views and to the final histologic diagnosis, made a diagnosis of the endocytoscopic images by reviewing the digital files of the images. The endocytoscopic diagnosis corresponded well with the final histological diagnosis with a 93.3 % accuracy rate and a kappa value of 0.910. The differential diagnosis between neoplastic and non-neoplastic lesions was 100 % correct. The sensitivity and specificity of the diagnostic ability of endocytoscopy on invasive cancer among the neoplastic lesions were 92.3 % and 100 %, respectively.

 Integrated-type endocytoscopy has been developed recently, providing an ordinary view, a magnified view up to ×80, and a highly magnified view of ×450 without any extra equipment. It is expected that the ultra-high magnified views will add more information to conventional magnification and make the diagnosis even more precise.

Copyright © 2006, Igaku-Shoin Ltd. All rights reserved.


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