Pyloric-Gland-Type Adenomas of the Stomach Ryoji Kushima 1 , Ken-ichi Mukaisho 2 , Michael Vieth 4 , Franz Borchard 5 , Manfred Stolte 6 1Division of Diagnostic Pathology, Shiga University of Medical Science 2Department of Pathology, Shiga University of Medical Science 4Institute of Pathology, Otto-von-Guericke University, Germany 5Institute of Pathology, Klinikum Aschaffenburg, Germany 6Institute of Pathology, Klinikum Bayreuth, Germany Keyword: 幽門腺型腺腫 , 胃型高分化型癌(胃型腺癌) , 病理診断 , 粘液 , CGH pp.1377-1387
Published Date 2003/9/25
DOI https://doi.org/10.11477/mf.1403100755
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 Pyloric-gland-type adenoma(PGA)is a rarely described neoplasia of the gastric mucosa which is composed of densely packed tubular structures varied in size with narrow stroma. Tumor cells are cuboidal to low-columnar in shape, having clear to eosinophilic cytoplasm and small round nuclei with conspicuous nucleoli. Tumorous glands are strongly positive for MUC6 and the superficial layer expresses MU5AC. PGAs occur predominantly in old age and more frequently in women. The site of predilection in the stomach is the corpus mucosa. In 20-30% of PGAs, transition to differentiated adenocarcinoma of predominantly gastric phenotype has been noted. Comparative genomic hybridization revealed some chromosomal abnormalities common to invasive stomach adenocarcinomas, suggesting an unstable condition of PGA. Endoscopists and pathologists should be on the lookout for this type of tumor in the stomach during routine examination.

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