Japanese

The Histopathological Risk Factors for Lymph Node Metastasis in Submucosal Invasive Colorectal Carcinomas Kazuaki Kitajima 1,2 , Takahiro Fujimori 2 , Shigehiko Fujii 2 , Toshihide Kumamoto 1 , Hidenobu Watanabe 3 1The Third Department of Internal Medicine, Oita University Faculty of Medicine 2Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine 3Division of Molecular and Functional Pathology, Department of Cellular Function, Graduate School of Medical and Dental Sciences, Niigata University Keyword: 大腸癌研究会sm癌取り扱いプロジェクト研究委員会 , 大腸sm癌 , リンパ節転移 , 絶対分類 pp.1329-1337
Published Date 2004/9/25
DOI https://doi.org/10.11477/mf.1403100564
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 The Japanese Society for Cancer of the Colon and Rectum analyzed Clinicopathological factors of865submucosal invasive colorectal carcinomas, from865patients who had undergone surgical resection at six institutions.

 In measuring the depth of submucosal invasion, submucosal invasive colorectal carcinomas were classified into two types, pedenculated and non-superficial types.

 When the muscularis mucosae could be identified in HE or Desmin stained specimens, the muscularis mucosae was used as baseline and the vertical distance from this line to the deepest portion of invasion represented the depth of submucosal invasion.

 When the muscularis mucosae could not be identified due to carcinomatous invasion, we determine the baseline according to the macroscopic types.

 For pedunculated SICC, a border between normal epithelium and neoplastic epithelium was used as baseline and the depth of submucosal invasion was measured as the vertical distance from this line to the deepest portion of invasion. When the deepest portion of invasion was limited to above the baseline, the case was defined as a head invasion and SM depth was regarded as0μm. When the deepest portion of invasion was located below the baseline, the case was defined as a stalk invasion and the vertical distance from this line to the deepest portion of invasion was the depth of submucosal invasion.

 For non-pedunculated SICC, the tumor surface was used as baseline, and the vertical distance from this line to the deepest portion of invasion represented the depth of submucosal invasion.

 For pedunculated SICC, the rate of lymph-node metastasis was0% in head invasion cases and stalk invasion cases with a depth of submucosal invasion<3,000μmif lymphatic invasion was negative. For non-pedunculated SICC, the rate of lymph-node metastasis was also0% if the depth of submucosal invasion was <1,000μm.

 1) The Third Department of Internal Medicine, Oita University Faculty of Medicine, Oita, Japan

 2) Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan

 3) Division of Molecular and Functional Pathology, Department of Cellular Function, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan


Copyright © 2004, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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