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Japanese

Effects of Antibiotic Administration on Colonic MALT Lymphoma Takashi Hisabe 1 , Yosuke Kikuchi 1 , Yoko Wada 1 , Tatsuhiro Oishi 2 , Sumio Tsuda 1 , Toshiyuki Matsui 1 , Akinori Iwashita 3 , Kensaburo Imamura 4 1Department of Gastroenterology, Fukuoka University Chikushi Hospital 2Department of Gastroenterology, Sada Kouseikai Sada Hospital 3Department of Pathology, Fukuoka University Chikushi Hospital 4Kensaburo Clinic Keyword: 大腸MALTリンパ腫 , 抗生剤投与 , H. pylori pp.345-355
Published Date 2006/3/25
DOI https://doi.org/10.11477/mf.1403100290
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 We examined clinical effects on colonic MALT lymphoma after administration of antibiotics in five of our cases and 10 reported cases. After antibiotic administration using the same treatment as that used for H. pylori eradication, the lesion disappeared in 12 cases and regressed in 3 cases. Therefore, the efficacy of antibiotic therapy for treating colonic MALT lymphoma was established definitely. In the 10 cases where the lesion had disappeared, the period of time up to the dissappearance of the lesion was a mean of 116.5 days and no relapse was observed after this period. The depth of tumor invasion was evaluated by endoscopic ultrasonography. All of the unresponsive MALT lymphomas were located in the submucosal layer. On the other hand, five of the responsive MALT lymphomas had infiltlated into the muscular layer or deeper. The characteristic appearance of the 3 cases that were unresponsive was multiple lesions and the mean age of these patients was more advanced than the age of the responsive cases. It is suggested that antibiotic administration may be considered to be the first choice of treatment for colonic MALT lymphoma.


Copyright © 2006, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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