Primary Early Mucosa-associated Lymphoid Tissue Lymphoma of the Colon, Report of a Case Jiro Watari 1,2 , Yutaka Orii 1 , Hiroki Tanabe 1 1Department of Gastroenterology, Asahikawa Kosei General Hospital 2The Third Department of Internal Medicine, Asahikawa Medical College Keyword: 大腸MALTリンパ腫 , X線所見 , 内視鏡所見 , EUS所見 , PCR法 pp.1115-1122
Published Date 1997/7/25
DOI https://doi.org/10.11477/mf.1403104982
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 A 61-year-old man received a close examination of the colon because feces' occult blood test was positive during a physical check-up in our hospital. Barium enema study showed two polypoid lesions in the sigmoid colon, one of which was a flat elevation measuring 30 mm in diameter with a granular to nodular surface, the other was a hemispherical polyp measuring 10 mm in diameter. In colonoscopic observation, these tumors showed a glossy yellowish-white surface with capillary proliferation. A flat yellowish-white lesion was also detected in the sigmoid colon in addition to these tumors. By histologic examination of biopsy specimens, all of them were suspected of MALT (mucosa-associated lymphoid tissue) lymphoma. High-frequency ultrasound probe showed a massive invasion in the submucosal layer. A definite diagnosis of B-cell lymphoma was obtained by the polymerase chain reaction, which disclosed a monoclonal rearrangement of immunoglobulin heavy chain gene. Final diagnosis after sigmoidectomy was diffuse lymphoma, medium cell type (MALT-type). Tumor invasion was limited to the submucosa without nodal involvement. In the literature, lymphoepithelial lesions and lymphoid follicles are shown to be less prominent in MALT lymphomas of the colon than those of the stomach. Endoscopic and histologic findings in the present case seem to be typical of MALT lymphoma of the colon in the early stage, although this is extremely rare.

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