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要旨 患者は68歳,男性.黒色便にて近医を受診し,消化管精査目的にて当院紹介となる.上・下部消化管内視鏡検査では異常を認めなかった.その後も黒色便を認め,貧血を呈したため,カプセル内視鏡を施行したところ,上部空腸に,潰瘍を伴う粘膜下腫瘍を認めた.ダブルバルーン内視鏡による生検組織の免疫組織学的検討でKIT陽性であり,GISTと術前診断し,空腸部分切除術を施行した.HE染色では紡錘形細胞が束状不規則に増生し,強拡大10視野中40個以上の核分裂像を認めた.免疫組織染色ではKIT陽性,CD34陰性,α-SMA陽性,NSE陽性で,筋原性・神経原性双方に分化を示す高悪性度のGISTと診断した.リンパ節転移は認めず,術後経過は良好である.
A 68-year-old man was referred to our hospital because of melena and anemia. Esophagogastroduodenoscopy and colonoscopy revealed no abnormal findings, so capsule endoscopy was performed. A submucosal tumor with a small ulcer was detected in the upper jejunum. Double-balloon endoscopy was performed to enable histological diagnosis. Immunostaining of the biopsy specimen proved to be KIT positive and the submucosal tumor was preoperatively diagnosed as GIST. Partial jejunectomy was carried out. Histological examination of the resected tumor revealed malignant GIST, but no metastasis was found. Since the operation, the patient has been doing well.
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