切除検体取り扱いの留意点

Basic Handling of Resected Specimens：Points and Tips to Remember

要旨●本稿では，大腸切除検体の適切な取り扱いについて，若手医師や研修医にも理解しやすい形で基本と要点を整理した．ホルマリン固定前の迅速な対応の重要性を示し，生検，内視鏡切除，外科切除の各検体に応じた展開，固定，画像撮影，切り出しの原則を解説した．さらにT1癌や進行癌，炎症性腸疾患関連腫瘍における組織標本作製の考え方にも触れ，診断精度向上には丁寧な肉眼観察と臨床・病理の連携が不可欠であることを強調した．

　In this article, we systematically summarizes the fundamental principles and key points in the proper handling of colorectal resection specimens, aimed at junior physicians and residents. It emphasizes the importance of prompt specimen management before formalin fixation and explains key steps such as specimen orientation, fixation, photographic documentation, and sectioning according to specimen type, including biopsy, endoscopic resection, and surgical resection. Furthermore, this study discusses the principles for processing all sectioned specimens into paraffin-embedded histologic slides in cases of T1 and advanced colorectal carcinomas, as well as neoplasms associated with inflammatory bowel disease. Ultimately, it emphasizes that careful gross examination and close collaboration between clinicians and pathologists are vital to achieving an accurate diagnosis.