認知症の神経病理

Neuropathology of Argyrophilic Grain Disease

Point

・認知症の背景病理は，アルツハイマー病やレビー小体型認知症，脳血管性認知症などのほかにも種々のものがあり，それぞれ予後などが異なる．

・高齢者では合併病理も多く，100%の臨床確定診断というのは未だに困難で，最終診断は剖検病理診断によらざるを得ない．

・蛋白をターゲットとして治療を開始し，剖検病理診断の結果をより臨床のバイオマーカーにフィードバックさせることで，精度の高い診断が求められる．

　Dementia is classified into various types with corresponding underlying pathologies, including Alzheimer's disease, dementia wiht Lewy bodies, and vascular dementia; final diagnosis is often possible only after a pathological examination during an autopsy. Furthermore, older adults often have comorbid pathologies that make clinical diagnosis even more difficult. While protein-targeted treatments are emerging, different dementia types have varying pathologies and prognoses, necessitating efforts to improve diagnostic accuracy while the patient is alive. To achieve this, autopsy diagnosis information must be correlated with clinical biomarker data.