両側のnevoid hyperkeratosis of the nipple and areola

・両側の乳頭から乳輪に対称性に生じたnevoid hyperkeratosis of the nipple and areola（NHNA）を経験した．

・患者は30歳代女性で，とくに妊娠歴，ピル内服歴，その他特記すべき既往歴や治療歴はみられなかった．

・個々の皮疹から色素性疣贅や脂漏性角化症との鑑別が比較的困難であった．

・病理組織学的に正常過角化や糸状吻合を伴う表皮肥厚と乳頭腫状の増殖があり，一部に空胞細胞がみられたが，human papillomavirus（HPV）は陰性であった．

・数回の液体窒素で完治し，その後再発はみられていない．

（「症例のポイント」より）

　

A case of bilateral nevoid hyperkeratosis of the nipple and areola

　

Futei, Yuko1） 1）Department of Dermatology, Ogikubo Hospital

　

Hyperkeratosis of the nipple and areola is a rare disease characterized by brownish verrucous plaques of the nipple, areola or both. Subclinical type of this disease predominantly occurring in females of child-bearing age is known as nevoid hyperkeratosis of the nipple and areola (NHNA). We report a case of bilateral NHNA in a 37-year-old female, with no history of pregnancy, estrogen therapy, or underlying disease. Histological examination revealed typical features of NHNA with hyperkeratosis, filiform acanthosis, papillomatosis, and keratotic plugging. She was successfully treated with cryotherapy.