ラットにおける脂肪と血清脂質値に及ぼす食餌制限の効果

Effect of long-term dietary restriction on visceral fat mass and serum lipid levels in male rats

［和文抄録］

　食餌制限ラットにおける体脂肪と血清脂質値の加齢変化を検討し、食事制限の利的効果がヒトにも及ぶかどうか考察した。自由摂取群と食餌制限群（自由摂取量の60％）ラットの体重、BMIを毎月計測し、内臓脂肪量、各種血清脂質を2、4、6、12、18、24、29、33ヵ月齢に定期屠殺し測定した。長期食餌制限されたラットの体重、BMI、中性脂肪は終生持続的に抑制され、食餌制限効果を判定する良い指標になると考えられた。血清アルブミン値は、月齢、群間とも有意差はなく、終生概ね一定の値を維持し、食餌制限による低栄養である見解は否定できた。実験と文献の検討により、長期食事制限は健康なヒトにおいても持続的な体重、体脂肪、血清脂質の抑制効果が期待できたことから、食事制限は生活習慣病の有効な一次予防策になり得ることが示唆された。

［英文抄録］

　Aging-related changes in body fat and serum lipid levels in diet-restricted rats were investigated to determine the extent of beneficial effects of dietary restriction on humans. The body weight and BMI of rats in an ad libitum group and diet-restricted group(restricted to 60% of the ad libitum intake) were measured monthly, and visceral fat mass and serum lipids of each type were measured at 2, 4, 6, 12, 18, 24, 29, and 33 months of age after animals were sacrificed. Body weight, BMI and triglycerides of rats subjected to a long-term restricted diet were suppressed for life, and this result is believed to be a good indicator for determining the efficacy of dietary restrictions.

　Serum albumin level was not significantly different by age or between groups, and as a rule maintained a fixed level for life, thus negating the view that dietary restriction sproduce poor nutrition. Dietary restriction may be an effective precautionary measure for lifestyle-relate diseases, since, according to both experiments and the published literature, long-term dietary restrictio ncan be expected to effectively suppress continuous body weight, visceral fat and serum lipids even in healthy people.