遺伝子関連検査の標準化と人材育成

Role for the standardization of genetic testing

　遺伝子関連検査は，感染症，血液疾患，悪性腫瘍などの診断において有用な検査法とし活用されている．また，技術的には定量化が進み，微量検出ならびに自動化も可能となってきている．しかし，測定方法は十分統一されているわけでなく，標準化に向けた取り組みの総括とそれを担う人材育成の推進が急務である．

On the basis of recent progeress in understanding of clinical implications, the genetic testing has been used for dianosis of various diseases and for selection of drugs and monitoring their effects.　To confirm the genetic testing as a diagnostic tool, laboratories performing genetic testing are needed to ensure quality assurance.　Accurate and precise of testing using nucleic acid extracted from various samples is important as a pre-analysis.　Pre-analytic processes as a clinical sampling affected the outcome of genetic testing.　Analysis of variance of gene-expression revealed small but significant differences between the handling methods.　Thus well-controlled sample processing and storage conditions are critical to the sensitive and potentially quantitative analysis of genetic testing.