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Peritumoral Hemorrhage after Radiosurgery for Metastatic Brain Tumor:A case report Takahiko MOTOZAKI 1 , Sadahiko BAN 2 , Toyoshiro YAMAMOTO 2 , Masatake HAMASAKI 3 1Department of Neurosurgery, Nishinomiya City General Hospital 2Department of Neurosurgery, Kobe City General Hospital 3Department of Neurosurgery, Shinsuma Hospital Keyword: Radiosurgery , Peritumoral hemorrhage , Brain metastasis , Hemodynamic change pp.789-793
Published Date 1994/8/10
DOI https://doi.org/10.11477/mf.1436900895

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  • Abstract
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An unusual case of peritumoral hemorrhage after radiosurgery for the treatment of metastatic brain tumor is reported. This 64-year-old woman had a his-tory of breast cancer and underwent right mastectomy in 1989. She remained well until January 1993, when she started to have headache, nausea and speech dis-turbance, and was hospitalized on February 25, 1993. Neurological examination disclosed right hemiparesis and bilateral papilledema.

CT scan and MR imaging showed a solitary round mass lesion in the left basal ganglia region. It was a well-demarcated, highly enhanced mass, 37mm in dia-meter. Cerebral angiography confirmed a highly vascular mass lesion in the same location.

She was treated with radiosurgery on March 8 (maxium dose was 20Gy in the center and 10Gy in the peripheral part of the tumor). After radiosurgery, she had an uneventful course and clinical and radiosurgical improvement could be detected. Her neurological symp-toms and signs gradually improved and reduction of the tumor size and perifocal edema could be seen one month after radiosurgery. However, 6 weeks after radiosurgery, she suddenly developed semicoma and right hemiplegia. CT scan disclosed a massive peritu-moral hemorrhage. Then, emergency craniotomy, eva-cuation of the hematoma and total removal of the tumor were performed on April 24. Histopathological diagnosis was adenocarcinoma. It was the same finding as that of the previous breast cancer. Histopathological examination revealed necrosis without tumor cells in the center and residual tumor cells in the peripheral part of the tumor.

It is postulated that peritumoral hemorrhage was caused by hemodynamic changes in the vascular-rich tumor after radiosurgery and breakdown of the fragile abnormal vessels in the peripheral part of the tumor.


Copyright © 1994, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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