悪性淋巴腫の電子顕微鏡像—特に抗癌剤使用時における内部微細構造の変化

ELECTRON-MICROSCOPIC OBSERVATIONS ON MALIGNANT LYMPHOMA DURING ANTITUMOR CHEMOTHERAPY

Ⅰ．はじめに

　皮膚に発生した悪性淋巴腫の電子顕微鏡的研究には，若干の報告^1）〜4），藤田，野口，辻村等のそれがあるが治療中における腫瘤について，治療前のそれと比較検討した報告は，筆者の知る限りでは認められない様である。しかし，今回，我々は光学顕微鏡で，細網肉腫の像を呈する2,3の症例について電子顕微鏡に依る観察を試みた結果，治療前に比較して，核膜の一部に興味ある所見を得たので報告する。

Electron-microscopic studies on the morphologic changes in the course of administration of antineoplastic agents (fluorouracil, etc.) in a case of reticulum-cell lymphoma of the skin were performed. Main changes were seen on the nuclear membrane and very diverse. Some of the nuclear membrane were detached from the nucleus, while others were swollen and showed a globular or annular shape containing inclusion body-like particles in them.

The degree of the changes seemed to go with the given dose of the drugs.

These findings could not be seen in the tumor cells before the treatment. They might be a kind of defense reaction of the tumor cells against the antineoplastic agents.

There were no significant changes in the amount of the cytoplasm and the degree of its electron density of the tumor cells before and after the use of the drugs

No changes of the same kind in the nuclear membrane were noted in the normal epidermal cells both before and during the therapy.