女子顔面再発性皮膚炎と化粧品

DERMATITIS FEMINEA RECIDIVANS FACIEI AND COSMETICS

Ⅰ．はじめに

　婦人の顔面に卒然として瘙痒に始まり，潮紅，落屑に終る再発性の皮膚炎について栗原^1）2）（1935，1940）が始めて報告して以来，同様の疾患について古賀^3）（1937），小森・花谷^4）（1939），次いで青島^5）の報告があり，青島^5）（1940）が始めて女子顔面再発性皮膚炎（皆見，青島）という病名を提唱，後に栗原^8）も同意している。その後大原^6）（1943）は本症89例を挙げて本症の臨床，病因等について実に詳細な検討を加えた。これにより本症は体系づけられた感があったが，最近になり再び本症の病因，或いは本症と他疾患との異同等について論議されている。

　そこで著者らは本症33例について患者の使用した化粧品の貼布試験を行い，更に皮膚と化粧品のpHの方面よりも多少の検索を行つたのでその結果を報告し，合せて本症の臨床，病因等についても多少考察してみたいと思う。

　Relationship between the onset of dermatitis feminea recidivans faciei and cosmetics used has been subjected to study. Patch test was carried out on 33 patients with the disease and 10 normal females. Three hundred and twenty nine cosmetics were examined for the patients and 74 cosmetics for the control persons respectively. The results were as follows:

　Amog the cosmetics which showed positive reaction, there were so called basic cosmetics such as foundations, base creams, lotions and so on.

　Photopatch test was carried out using 182 patients. At the end of 24 hours after a cosmetic was applied, the skin was irradiated for 5 minutes at a distance of 50 cm with the artificial sun light. Eighteen patients showed positive reaction with respect to 23 cosmetics among 182 cosmetics tested.

　The pH value on the skin surface where cosmetics are usually applied was also determined in order to study whether cosmetics might give any influences on the pH value on the skin surface. Most of the cosmetics have relatively high pH values. the Torehead and flexure of the arm of each 30 normal males and normal females were used for the determination. The pH values obtained on the forehead of the females were much higher than those of the males and also those obtained on the arms of the females.

　These experimental results might indicate that a cosmetic is one of the causes of dermatitis feminea recidivans faciei.