頭蓋内主幹動脈遮断による各種脳梗塞モデル犬の作製

PRODUCTION OF VARIOUS CEREBRAL INFARCTION MODELS IN THE DOG BY MEANS OF OCCLUSION OF INTRACRANIAL TRUNK ARTERIES

　脳梗塞は、その疾患がpopularであるにもかかわらず，発症後のdynamicに変化する脳実質の病態生理，循環動態などの変化の究明はなお不十分といわざるを得ない。理由は、脳梗塞の理想的実験動物モデルの作製やがきわめて困難であつたためである。

　さて，脳梗塞の理想的実験動物モデルの条件は、まず廉価で入手が容易であること，脳血管に不特定の奇形が少ないこと，同一部位に同一程度の梗塞巣が高頻度に作製できること，梗塞の程度は人為的に自由にコントロールができ，しかも薬剤の作用を正確に判定できるものであり，できるならば，動物はそのまま生存して，慢性実験も可能であるにとである。

Knowing that, by use of a surgical microscope and a unilateral temporal approach, all of the bi-lateral trunk arteries at the base of the skull indogs can be identified and treated, we succeeded in producing various infarction models by means of simultaneously occluding the vessels in various combinations. These infarction models include: unilateral or bilateral complete cerebral hemisphere infarction models, a unilateral hemispheric and contralateral cerebral mantle infarction model, a unilateral thalamic and contralateral cerebral mantle infarction model, etc. In the anterior thalamic infarction model, the severity of infarction foci can be regulated by the time of vessel occlusion, and chronic experiments achieved. In the otherinfarction models, however, severe edema is seen following recirculation after more than one hour occlusion, making them unsuitable as models for chronic infarction. Nontheless, it is thought that such models have great value as models of brain edema and these various models for cerebral infarction in the dog will prove valuable in clari-fying many of the outstanding problems with regard to the basic science of the cerebral hemi-spheres.