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SUPPRESSION OF INFARCTIC CHANGES WITH MANNITOL AND FLUOROCHEMICALS : AN EXPERIMENTAL STUDY Satoru Tanaka 1 , Hirobumi Seki 1 , Takashi Yoshimoto 1 , Jiro Suzuki 1 1Division of Neurosurgery, Institute of Brain Diseases, Tohoku University School of Medicine pp.1141-1146
Published Date 1981/11/1
DOI https://doi.org/10.11477/mf.1406204850
  • Abstract
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We have developed and previously reported a canine model for diffuse, incomplete cerebral hemi-sphere infarction produced by simultaneously occluding the following 5 arteries unilaterally at the base of the brain: the A2 portion of the anterior cerebral artery, the A1 portion of theanterior cerebral artery at the bifurcation of the ethmoidal artery, the internal carotid artery, the posterior cerebral artery at the bifurcation of the posterior communicating artery and the anterior cerebellar artery. After 6 hours of occlusion, recirculation was allowed, and sequential observa-tion was made on the degree of brain swelling. Investigation was made on whether or not admi-nistration of 20% mannitol or fluorocarbon emulsi-on (20% fluosol DA) following vascular occlusion is effective in suppressing such swelling. It was found that brain swelling could be prevented using by mannitol and fluorocarbon emulsion together, but not mannitol and fluorocarbon emulsion alone.

Based on these results, we found that mannitol administered together with fluorocarbon emulsion has a protective effect for cerebral infarction follow-ing 6 hours vascular occlusion.


Copyright © 1981, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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