Fluphenazine Enanthateの接触障害に対する効果について—陳旧性分裂病の生活療法の中での薬物療法再検討の経験から

EFFECT OF FLUPHENAZINE ENANTHATE IN THE RESTORATION OF CONTACT:STUDY OF PSYCHOPHARMACOTHERAPY IN CHRONIC SCHIZOPHRENIA IN THE COURSE OF MILIEU THERAPY

Ｉ．はじめに

　Kinross-Wright J．　^3）らによって，long active Fluphe—nazine （F．　E．と略す）の臨床的有用性がみとめられて以来，それを支持する数多くの報告がある。我国においても，すでに，三浦ら^8），松本ら^7），佐野ら^6），大高ら^1），加藤ら^2），などの報告があり，向精神薬療法の中で，本剤の大体の位置づけはなされているように思われる。これらの報告を綜合すると，およそ次のようにまとめることができる。

　（1）臨床効果のスペクトラムは従来のFluphenazineとほぼ同じであるが，拒絶傾向のつよいものに特に有効である。陳旧例の問題行動や無為自閉傾向及び疎通性の改善にはみるべきものがある（三浦ら^8），松本ら^7））。

We examined the effect of Fluphenazine Enan-thate in schizophrenic patients in the course of milieu therapy. The number of patients who were given this drug was 33 cases. 8 cases of these were in acute state, and 25, in chronic deteriorated state. Each patient was given 1 or 2 vials of Fluphenazine Enanthate weekly or fortnightly.

The result was as follows : 6 of 8 acute cases were excellent or good and 13 of 25 chronic cases, good. This shows the high potency of Fluphena-zinc Enanthate. Initial manifestation of efficacy was in two to four days. The characteristic of this drug was excellent effect in patient's recovery of contact with therapist. Effect in drug refusal pa-tients, which has been emphasized, was thought due to this fact.

According to the results of the rating scale, therestoration of contact seems to be due to anti-anxietyand-delusional effects particulary in acute cases, aswell as activating effect on emotional disturbancein chronic cases.

Considering effect for contact, we should bear inmind the side-effect and how to treat it. That is,its therapeutic consideration is very important.