Behcet病にクローン病が合併したと考えられる症例

A Case Report of Behcet Disease Which Seems to Be Associated with Crohn's Disease

　クローン病¹⁾に，Behcet病²⁾の眼症状を除く不全型を合併した症例を経験し，手術により救命しえたが，われわれが文献的に調査した範囲では，このような合併例の報告は極めて珍しく，諸外国も含めて2例⁴⁾⁵⁾のみである．

　クローン病および腸型Behcet病は，共に回盲部に好発するが，消化管のいずれの部位をも侵しうる疾患である．しかし，前者は小腸大腸を中心とする消化器疾患であるのに対し，Behcet病はmuco-cutaneous-oculo-uveal syndromeともすべき全身性炎症性疾患で³⁾，その副症状の1つとして腸炎を合併することがある．これが腸型Behcetで，クローン病の腸管病変とかなりの相違が認められている²⁴⁾．

　We experienced a rare case of Behcet disease which seems to be associated with Crohn's disease.

　So far, only two cases of these association have been reported in the literature and our case was the third one.

　Analysis was made on these three cases and we found some similarities between them, namely 1) sex distribution was predominant at younger female, 2) Behcet disease itself was an incomplete type except for occular lesion and 3) early intestinal lesions were typical as Crohn's disease.

　We also compared Behcet's three major symptoms (besides occular lesion) to the Crohn's oral, genital and skin lesions, then discussed three major symptoms of our case.

　Our oral lesions showed cobblestone formation and linear ulcers which were typical as Crohn's disease but have never been reported in Iapan.

　There was a trend of increasing B5 of HLA among 4 cases of intestinal Behcet disease, 5 cases of Crohn's disease and 40 cases of ulcerative colitis.