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Change of Histological Type of Gastric Carcinoma: From Differentiated Carcinoma to Undifferentiated Carcinoma Shingo Ishiguro 1 , Tsutomu Kasugai 1 , Nobuyuki Terada 1 1Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases Keyword: 組織型の変化 , 胃癌 , 分化型 , 未分化型 , 混合型 , 深達度 , 癌の進展 pp.1437-1443
Published Date 1996/11/25
DOI https://doi.org/10.11477/mf.1403104445

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  • Abstract
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 Two hundred and forty six cases of submucosal invasive gastric carcinoma were examined to discover the change of histological type as the carcinoma develops. Histological type of carcinoma was divided into three types; pure differentiated-type, pure undifferentiated-type and mixed-type. Mixed-type means a type somewhere between differentiated and undifferentiated.

 Clinicopathologically, the mixed-type group and the group whose histological type was different in the submucosa from where it was in the mucosa were an intermediate group between the pure well-differentiated-type group and pure undifferentiated-type group.

 The histological cahnge of differentiated-type took place in the mucosa and the submucosa. In the mucosa, the differentiated-type changed into mixed-type with increasing diameter. In the superficial zone of submucosa, differentiated-type changed into the mixed-type and the mixed-type changed into the undifferentiated-type in the deep zone of the submucosa.

 It was concluded that a differentiated-type carcinoma changed into an undifferentiated-type carcinoma, passing through a mixed-type stage, and eventually to an undifferentiated-type carcinoma. The ratio of undifferentiated-type to differentiated-type carcinoma increased as the development of the carcinoma increased.


Copyright © 1996, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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