Japanese

Distinctive Feature and Histogenesis of Undifferentiated Carcinoma of the Stomach Shingo Ishiguro 1 , Haruo Taniguchi 1 , Ryuuhei Tateishi 1 , Akira Wada 1 1Department of Pathology, The Center for Adult Diseases, Osaka pp.1345-1352
Published Date 1989/12/25
DOI https://doi.org/10.11477/mf.1403106635
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 One hundred and twenty-two lesions of small gastric carcinoma measuring 10 mm or less in the greatest diameter were histologically reviewed to clarify cellular origin of undifferentiated carcinomas.

 Histological classification of the 122 carcinomas were as follows: intestinal type differentiated carcinoma 78, gastric type differentiated carcinoma (foveolar type adenocarcinoma) 15, signet ring cell carcinoma or poorly differentiated adenocarcinoma (pure undifferentiated carcinoma) 9, mixed pure undifferentiated carcinoma and differentiated carcinoma (mixed type carcinoma) 10 and undetermined type carcinoma 10.

 Pure undifferentiated carcinomas were located in the fundic glandular zone, intermediate zone and/or mild intestinal metaplastic zone without fundic gland. On the other hand, mixed type carcinomas and foveolar type carcinomas were located in the intermediate zone and/or mild intestinal metaplastic zone without fundic gland.

 These facts suggested that both pure undifferentiated carcinomas and mixed type carcinomas arose from the proper gastric mucosa, and that mixed type carcinomas arose from the proper gastric mucosa with more atrophic and metaplastic changes than that for pure undifferentiated carcinomas.

 It is assumed that the histological type of gastric carcinoma changes continuously from pure undifferentiated carcinoma to differentiated carcinoma as the gastric mucosa changes from the proper type to the metaplastic type.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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