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Fractal Analysis of Pit Patterns and Histologies: A Novel Finding for Correlation between Macroscopic and Microscopic Features of Colorectal Neoplasias Yoichi Ajioka 1 , Hidenobu Watanabe 1 1The First Department of Pathology, School of Medicine, Niigata University Keyword: pit pattern , フラクタル次元 , 大腸腫瘍 , 微細表面性状 pp.1599-1606
Published Date 1999/12/25
DOI https://doi.org/10.11477/mf.1403102889

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  • Abstract
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 The fractal dimensions of pit patterns (shapes and the arrangement arranging pattern of the orfice of the crypts) and their corresponding histology (tubular structure) by H・E sections were analysed and compared in 55 colonic intramucosal epithelial neoplasias (37 adenomas, seven carcinomas with low-grade atypia and 11 carcinomas with high-grade atypia) . The pit patterns were classified into round, roundish, tubular and branching and their average fractal dimensions were 1.06, 1.27, 1.39, 1.57, respectively. The more complex and irregular the pit patterns were the higher the fractal dimensions. Positive correlation was found between the fractal dimension of the pit pattern and the corresponding histology, indicating that pit patterns quantitatively reflect the structural atypia of the tumor. There was a significant difference in both pit pattern and histology and also in fractal dimension according to whether the lesions were adenoma or carcinoma (both low-grade and high-grade). The difference in the fractal dimensions of low-grade and high-grade carcinomas was not significant either histologically (1.49 vs. 1.51, p=0.72), or by the pit pattern trends (1.55 vs. 1.61, p=0.15). These data imply that pit pattern may reflect not only the structural atypia but also the cellular atypia of colonic intramucosal epithelial neoplasia.


Copyright © 1999, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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