hereditary papulotranslucent acrokeratoderma

・hereditary papulotranslucent acrokeratoderma（HPA）は，思春期に発症する掌蹠の多発性角化性丘疹を特徴とする常染色体優性遺伝である．

・HPAは治療抵抗性であり，また日常生活に支障をきたすことがほとんどないため放置されていることが多い．

（「症例のポイント」より）

　

A case of hereditary papulotranslucent acrokeratoderma

　

Morishima, Miya1）Uno, Yu1）Nobeyama, Yoshimasa1）Ishiji, Takaoki1）Asahina, Akihiko1）Koda, Masato2） 1）Department of Dermatology, The Jikei Univercity School of Medicine 2）Aozora Dermatology Clinic

　

A 54-year-old woman presented with white papules of the palms and soles that began in young adulthood. Histopathological examination showed hyperkeratosis, hypergranulosis and acanthosis in the epidermis. Elastictissue stain of the sections demonstrated no striking decrease in the number of elastic fibers of the dermis below the area of epidermal involvement, and no fragmentation of the elastic fibers. The physical examination and histopathologic findings are consistent with hereditary papulotranslucent acrokeratoderma.