関節リウマチに合併したself-healing papular mucinosis

・当科で経験した脛骨前粘液水腫（pretibia-lmyxedema，以下PTM）の2例のうち，1例はBasedow病，1例は橋本病患者であった．

・関節リウマチ（rheumatoid arthritis；以下，RA）に合併した左手関節部屈側のself-healing papular mucinosis（以下，SHPM）を経験した．

・生検施行後，病変の退縮傾向を認め，生検半年後に完全に消褪した．

・成人型のSHPMは12例の報告があり，そのうち自験例は最高齢である．

・長期にわたるRA罹患歴がSHPM発症になんらかの影響を及ぼす可能性が推測された．

（「症例のポイント」より）

　

A case of self-healing papular mucinosis of a Japanese female associated with rheumatoid arthritis

　

Tohda, Rie1）Kamei, Chisato1）Shimizu, Nami1）Okabayashi, Aya1）Nakagawa, Koichi1） 1）Department of Dermatology, Saiseikai Tondabayashi Hospital

　

A 75-year-old Japanese woman presented with a month history of asymptomatic slightly reddish papules on the front of left wrist. The papules ranged from 2 to 5 mm in diameter. She had been suffering from rheumatoid arthritis for 17 years. Histological examination revealed mucin deposit in the upper and mid dermis with proliferation of fibroblasts and perivascular infiltrate of inflammatory cells. Six months after the skin biopsy, the lesions resolved spontaneously without treatment. It was guessed that the long history of rheumatoid arthritis might participate in the occurrence of this disorder.