Body weight and bone/calcium metabolism. The effect of incretin hormones on bone and calcium metabolism. Kinoshita Yuka 1 1Division of Nephrology & Endocrinology, Department of Medicine, The University of Tokyo Hospital, Japan. pp.933-939
Published Date 2018/6/28
DOI https://doi.org/10.20837/4201807933
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 Incretins are gastro-intestinal hormones released from enteroendocrine cells in response to food intake. Incretins such as glucose-dependent insulinotropic peptide(GIP)and glucagon-like peptide 1(GLP-1)modulate glucose homeostasis by regulating glucose-dependent insulin release from pancreatic βcells. Dipeptidyl peptidase-4(DPP-4)inhibitors and GLP-1 receptor agonists are incretin-based drugs that have been used for the management of hyperglycemia and obesity in patients with type 2 diabetes mellitus. Although experimental studies have shown that incretin improves bone quality and increases bone mass in rodents, further studies are necessary to clarify the effect of incretin-based drugs on bone mineral density and risk of fractures in humans.


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