Updates on Lifestyle-Related Diseases and Bone Metabolism. The relationship between incretin and bone metabolism. Kanazawa Ippei 1 1Internal Medicine 1, Shimane University Faculty of Medicine, Japan. pp.1671-1677
Published Date 2014/10/28
DOI https://doi.org/10.20837/4201411091
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 There are two kinds of incretin, glucose-dependent insulinotropic polypeptide(GIP)and glucagon-like peptide-1(GLP-1).GIP directly affects osteoblasts and osteoclasts, resulting in increasing bone mass by enhancing bone formation and suppressing bone resorption. On the other hand, GLP-1 does not affect bone directly. GLP-1 is reported to stimulate calcitonin secretion in thyroid gland and then indirectly increase bone mass. Dipeptidyl peptidase-4 inhibitors, which activate the function of incretin, may decrease the risk of osteoporotic fractures. In addition, it has been shown that osteoblast-derived osteocalcin stimulates GLP-1 secretion. Therefore, there may be an interaction between bone and digestive tract.


電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社