Development of fluorescent probes for bone imaging in vivo ~Fluorescent probes for intravital imaging of osteoclast activity~. Minoshima Masafumi 1 , Kikuchi Kazuya 2 1Graduate School of Engineering, Osaka University, Japan. 2Graduate School of Engineering, Osaka University/Immunology Frontier Research Center, Osaka University, Japan. pp.187-191
Published Date 2018/2/28
DOI https://doi.org/10.20837/4201802187
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 Fluorescent molecules are widely used as a tool to directly visualize target biomolecules in vivo. Fluorescent probes have the advantage that desired function can be rendered based on rational design. For bone-imaging fluorescent probes in vivo, they should be delivered to bone tissue upon administration. Recently, a fluorescent probe for detecting osteoclast activity was developed. The fluorescent probe has acid-sensitive fluorescence property, specific delivery to bone tissue, and durability against laser irradiation, which enabled real-time intravital imaging of bone-resorbing osteoclasts for a long period of time.


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