Japanese

Frontiers in Live Bone Imaging Researches. Development of fluorescent pH probe for imaging osteoclast activation. Kikuchi Kazuya 1 , Kowada Toshiyuki 2 , Maeda Hiroki 3 1Department of Material and Life Science, Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, Japan. 2Department of Material and Life Science, Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, Japan. 3Department of Material and Life Science, Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, Japan. pp.877-882
Published Date 2015/5/28
DOI https://doi.org/10.20837/4201506093
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 For the clinical diagnosis of osteoporosis, X-ray CT and biochemical bone metabolism markers, however, there is no method to monitor osteoclast activity in the living system. We have developed the fluorescent probe to monitor osteoclast activity, by the combination of pH sensitive fluorescent dye with bisphosphonate which is delivered to the bone surface by its high affinity to hydroxyl apatite, which is named BAp-E. In vivo mouse imaging of activated osteoclast was successfully demonstrated using two photon excitation laser microscope.



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電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社

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