Calcium and bone metabolism across women's life stages. Molecular mechanisms underlying bone metabolism by estrogen. Imai Yuuki 1 1Division of Integrative Pathophysiology, Proteo-Science Center, Department of Pathophysiology, Graduate School of Medicine, Division of Experimental Animal Research, Advanced Research Support Center, Ehime University, Japan. pp.635-641
Published Date 2017/4/28
DOI https://doi.org/10.20837/4201705027
  • Abstract
  • Look Inside
  • Reference

 Osteoporosis, which patients are estimated as more than 13 million in Japan, is mainly caused by postmenopausal osteoporosis. Estrogen deficiency induced by menopause can disturb endocrine feedback and homeostasis, followed by bone loss by increased bone resorption with high bone turnover. Recent studies using systemic or conditional Estrogen Receptor α(ERα)gene knockout mice have unveiled molecular mechanisms underlying bone metabolism. In this review, it will be discussed that direct and indirect effects of estrogen and its metabolites for bone metabolism.


電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社