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An update on bisphosphonates and trends in drug therapy for osteoporosis. Effects of zoledronic acid on osteoporosis patients in Japan. Tanaka Sakae 1 1Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Japan. pp.257-261
Published Date 2017/1/28
DOI https://doi.org/10.20837/4201702083
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 Zoledronic acid is a bisphosphonate with the most potent anti-bone resorbing activity. Several previous studies demonstrated that zoledronic acid once a year significantly reduced the risk of vertebral, non-vertebral, and hip fractures in postmenopausal women. In a phase Ⅲ 2-year placebo-controlled, randomized, double-blind comparative study in Japan(ZONE study)demonstrated that once-yearly infusion of zoledronic acid 5 mg increased lumbar spine and proximal femoral BMD, and reduced the incidence of vertebral and non-vertebral fractures in Japanese patients with primary osteoporosis compared to placebo.



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電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社

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