Volume 24, Issue 8 (July 2014)
Japanese

Bone and Calcium Abnormalities in Malignancy. Bone metastases of breast cancer. Hata Kenji 1 , Yoneda Toshiyuki 2 1Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Japan. 2Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Japan./Devision of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, USA. pp.1177-1184
Published Date 2014/7/28
DOI https://doi.org/10.20837/4201408053
  • Abstract
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 Bone is one of the most preferential metastatic target sites for cancers. The biological crosstalk between metastatic cancer cells and bone microenvironment is critical to the pathopysiology of bone metastases. For example, It is well established that PTH-rP production in cancer cells stimulated by bone-derived TGF-β facilitates bone metastasis through promoting bone resorption by osteoclasts, thereby establishing “vicious cycle” between metastatic cancer cells and bone. In addition, recent studies identified several new players including platelets and MDSCs which contribute to the development of bone metastasis. In this review, we will overview the current topics on the mechanism by which bone metastasis is modulated at cellular and molecular levels.



基本情報

09175857.24.8.jpg
CLINICAL CALCIUM
24巻8号 (2014年7月)
電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社

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