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Osteoregulation by Physiological Stresses. Endoplasmic reticulum stress response in osteogenesis. Saito Atsushi 1 , Imaizumi Kazunori 2 1Department of Biochemistry, Institute of Biomedical & Health Sciences, University of Hiroshima, Japan. 2Department of Biochemistry, Institute of Biomedical & Health Sciences, University of Hiroshima, Japan. pp.1569-1575
Published Date 2013/10/28
DOI https://doi.org/10.20837/4201311021
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 Various cellular conditions such as synthesis of abundant proteins, expressions of mutant proteins and oxidative stress lead to accumulation of unfolded or misfolded proteins in the endoplasmic reticulum(ER)lumen. This type of stress is called ER stress. The excessive ER stress causes cellular damages followed by apoptosis. When ER stress occurs, cells are activated ER stress response(unfolded protein response)to avoid cellular damages. Recently, it has been clear that ER stress response plays crucial roles not only in cell survival after ER stress but also in regulating various cellular functions and tissue formations. In particular, ER stress and ER stress response regulate protein quality control, secretory protein production, and smooth secretion of proteins in the cells such as osteoblasts which synthesize and secrete enormous matrix proteins.



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電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社

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