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Comparable effectiveness of budesonide/formoterol combination and inhaled corticosteroid alone for the treatment of cough variant asthma Jun Tamaoki 1 , Ayako Kubo 2 , Kaori Hara 2 , Rie Mizobuchi 2 , Akitoshi Sato 2 , Yuri Simizu 2 , Sayo Fujimoto 2 , Yoshihide Atsumi 2 , Mami Orimo 2 , Keisuke Orimo 2 , Hiroko Hara 2 , Ken Arimura 2 , Katsunori Ochiai 2 pp.278-285
Published Date 2016/1/15
DOI https://doi.org/10.20837/3201602116
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 Cough variant asthma(CVA)is defined as asthma with cough as sole symptom, and one of the most common causes of chronic persistent cough, in which eosinophilic airway inflammation may play an important role. Although current guidelines recommend bronchodilators and anti-inflammatory drugs for the treatment, comparison of the efficacy of these medications has not been investigated. To evaluate the effectiveness of inhaled budesonide/formoterol combination(BFC)and inhaled fluticasone propionate(FP)in the treatment of CVA, 45 patients with newly diagnosed CVA were assigned to receive BFC(160/4.5μg, 1 inhalation twice daily)or FP(200μg, 1 inhalation twice daily)for 8 weeks. Primary outcome measure was cough symptom scores, and secondary outcome measures were pulmonary function, cough symptom assessed by CASA-Q and eosinophilic airway inflammation. The BFC group showed significant improvement in cough symptom scores as compared with the FP group. Eosinophil counts and eosinophil cationic protein contents in the induced sputum decreased in the two treatment groups with the same magnitudes. Although BFC and FP have equipotent effects for suppressing eosinophilic airway inflammation, treatment with BFC provided improvements in cough symptoms to a greater extent than did FP in patients with CVA.



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電子版ISSN 印刷版ISSN 1344-6932 医薬ジャーナル社

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