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Clinical efficacy of clarithromycin(800mg/day)against community-acquired adult pneumonia Niki Yoshihito 1 , Takeda Hiroaki 2 , Sakayori Susumu 3 , Miyashita Naoyuki 4 , Kishi Kenji 5 , Takahashi Toshihiro 6 , Doi Toshinori 7 , Notsute Daisuke 8 , Hidaka Toshiaki 9 , Kitani Michitaka 10 , Yamamoto Taro 11 , Setoguchi Keisuke 12 , Uchiyama Kazuaki 13 , Okuda Takeshi 14 , Kuroda Masahiko 15 , Yanagisawa Masatoshi 16 , Kawanishi Masayoshi 17 , Miura Hiroshi 18 , Hanaki Hideaki 19 , Sato Keizo 20 , Kadota Jun-ichi 21 Keyword: 成人市中肺炎 , 高用量(800mg/日)クラリスロマイシン , 原因菌 pp.120-130
Published Date 2017/4/25
DOI https://doi.org/10.20837/2201705120
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 In this study, we evaluated the clinical efficacy of high-dose(800mg/day)clarithromycin(CAM)against community-acquired adult pneumonia. Of the 15 cases registered in this study, 9 were subjected to efficacy analysis, and treatment was shown to be effective in all 9 cases. Pathogenic bacteria were detected in four cases:one case of mixed infection with Streptococcus pneumoniae and Mycoplasma pneumoniae, and three cases of independent infections with M. pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. S. pneumoniae and M. pneumoniae(independent infection)were macrolide-resistant strains;however, bacteriological and clinical efficacies of CAM were persistent and effective, respectively, in both cases, and clinical symptoms alleviated. Safety was evaluated in 15 cases, and no clinical side effects related to CAM were observed. These results indicate that high-dose(800mg/day)CAM is effective against community-acquired pneumonia in adults.



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電子版ISSN 印刷版ISSN 0913-2384 医薬ジャーナル社

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