The usefulness of the switch from intravenous to oral antibiotic therapy for patients with community-acquired pneumonia in Japan:the role of respiratory quinolones Yanagihara Katsunori 1 1Department of Laboratory Medicine, Nagasaki University School of Medicine Keyword: 市中肺炎 , スイッチ治療 , 切り替え基準 , レスピラトリーキノロン , ガレノキサシン pp.102-111
Published Date 2015/3/25
DOI https://doi.org/10.20837/2201504102
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 The switch from intravenous to oral antibiotic therapy is recommended for treating hospitalized patients with community-acquired pneumonia(CAP). We performed a multicenter, randomized study to assess the benefit of switching from intravenous to oral antibiotics in patients with CAP. Among adult CAP patients who must be hospitalized for intravenous antibiotic treatment, those with Pneumonia Patient Outcomes Research Team(PORT)scores of II - IV (mild to moderate)were enrolled. The criteria for switching(improved respiratory symptoms, CRP<15mg/dL, adequately improved oral intake, fever ≤ 38℃ for ≥ 12h), were adequate. Converting to respiratory quinolone was as effective as continuous intravenous treatment in mild to moderate CAP patients in whom initial intravenous antibiotic treatment was successful. The respiratory quinolone is one of the best antibiotics as oral antibiotics.


電子版ISSN 印刷版ISSN 0913-2384 医薬ジャーナル社