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Japanese

The effect of transcutaneous electrical stimulation for denervation on muscle atrophy and reinnervation muscle in nerve-crush rat model Kounosuke Tomori 1 , Ryuji Kobayashi 2 , Minoru Okita 3 , Jiro Nakano 4 , Toshiro Yoshimura 4 1Faculty of Health and Social Work School of Rehabilitation, Kanagawa University of Human Services 2School of Health Science, Kibi International University 3Faculty of Care and Rehabilitation, Seijoh University 4School of Health Science, Nagasaki University Keyword: (筋萎縮) , (神経再生) , 経皮的電気刺激 , Muscle atrophy , Nerve regeneration , Transcutaneous electrical stimulation pp.230-238
Published Date 2006/6/15
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 The purpose of this study was to determine whether transcutaneous electrical stimulation for denervation muscle effect both muscle atrophy and reinnervation. Eighteen seven-week-old male Wistar rats were divided randomly as follows : control (n = 6), stimulus group (ES group ; n=6), and non-stimulus group (N-ES group ; n=6). In the ES and N-ES groups, a bilateral sciatic nerve was crushed. The triceps surae muscles of rats in the ES group were electrically stimulated, 30 minutes/day for 2, 4 weeks. As a condition of electrical stimulation, the strength was set at 4 Hz, frequencies were set at 10 Hz, and duration was set at 250μsec. Following the experiment, both bilateral soleus muscle and sciatic nerve were removed for histological examination. Mean muscle fiber diameter in the ES group was significantly larger than that of group N-ES both at 2 and 4 weeks. The density of myelinated fibers and mean axon diameter showed no significant difference between the ES group and the N-ES group at 2 weeks, but at 4 weeks, those in the ES group were significantly larger than that of group N-ES. These results suggested that electrical stimulation for denervation muscle inhibits the progress of denervation muscle and leads to regeneration of injury nerve.


Copyright © 2006, Japanese Association of Occupational Therapists. All rights reserved.

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電子版ISSN 印刷版ISSN 0289-4920 日本作業療法士協会

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