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要旨:近年,随意運動の制御には大脳皮質と皮質下の複数組織が,ネットワークとして関与していることが明らかにされてきた.本研究の目的は,視覚誘導による母指と示指の精密把握にて,目標の高さまで反復して小物体を摘み上げる運動に関わる脳の賦活部位を解明することである.健常者23名を対象とし,H215OをトレーサーとしたPET(ポジトロン断層撮影法)を使用して,視覚誘導精密把握運動中の局所脳血流を測定した.安静時と比較した結果,運動中には一次運動野(M1),一次感覚野(S1),運動前野(PM),補足運動野(SMA),帯状回運動野(CMA),頭頂葉(BA7),前頭葉(BA11),後頭葉(BA17,18),視床,小脳に有意な賦活を得た.
The neural network governing voluntary motor control is now known to be distributed over multiple cortical and sub-cortical structures. The aim of this study was to elucidate the functional brain areas associated with a task of lifting a small object repetitively to a target using a visually guided precision grip between the index finger and thumb. An H215O positron emission tomography (PET) was performed to measure regional cerebral blood flow in 23 normal volunteers who performed the task. A comparison between visually guided precision grip and the rest condition (eyes closed) revealed significant activation of the primary motor area (Ml), primary sensory area (SI), pre-motor area (PM), supplementary motor area (SMA), cingulated motor area (CMA), parietal cortex (BA7), frontal cortex (BA11), occipital cortex (BA17, 18), thalamus and cerebellum.
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