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Immunology of ARDS Jun KATAOKA 1 1Department of Critical Care Medicine Nerima Hikarigaoka Hospital pp.651-663
Published Date 2023/10/1
DOI https://doi.org/10.11477/mf.3102201129
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Acute respiratory distress syndrome (ARDS) is a noncardiogenic pulmonary edema primarily due to an immunological response triggered in the lungs and systemic setting after “injury”. It results in severe hypoxemia,and the mortality rate for patients with severe ARDS exceeds 30% even with today's advances in medical science. Despite numerous drug therapies,no drug has been proven to prevent the onset and progression of ARDS and to improve mortality,which is thought to be due in part to the heterogeneity of ARDS,with individual patients having different degrees of pulmonary and systemic injury and immunologic responses to ARDS. In recent years,clinical trials have been conducted to examine the effect of drug therapy on ARDS by dividing the disease into high and low inflammatory sub-phenotypes using biomarkers, and stem cell therapy for ARDS is being planned and implemented. Furthering our understanding of the “immunology of ARDS” may therfore lead to breakthrough in ARDS treatment.


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電子版ISSN 2186-7852 印刷版ISSN 1883-4833 メディカル・サイエンス・インターナショナル

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