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多剤耐性結核症(MDR-TB)は,患者側の不適切な服薬や,医療従事者側の不適切な治療によって作られるman-made diseaseである.結核治療を開始する際には,すべての結核患者から適切な検体を採取し薬剤感受性検査を行い,早期に診断を行うことが必要となる.また,他者への感染を防ぎ新たなMDR-TBをつくらないことが重要である.
MDR-TB (multi-drug resistant tuberculosis) is defined as tuberculosis that is resistant at least to INH (isoniazid) and RFP (rifampicin), the two powerful first-line anti-TB drugs. MDR-TB develops during treatment of fully sensitive TB when the course of antibiotics is interrupted and the levels of drug in the body are insufficient to kill 100% of bacteria. This can happen for a number of reasons : Patients may feel better and halt their antibiotics course, drug supplies may run out or become scarce, or patients may forget to take their medication from time to time. MDR-TB is spread from person to person as readily as drug-sensitive TB and in the same manner. MDR-TB is a man-made-disease. We need a drug sensitivity test to start treatment. Treatment results of MDR-TB are not satisfactory. But we need to prevent new MDR-TB cases.
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