Clinical laboratory test of jaundice and abnormalities in bilirubin Susumu Itoh 1 , Tetsuya Kunikata 1 1Department of Pediatrics, Faculty of Medicine, Kagawa University Keyword: 化学構造 , 抱合ビリルビン , 非抱合ビリルビン , 光異性体 , ビリルビン代謝異常 pp.497-502
Published Date 2012/5/15
DOI https://doi.org/10.11477/mf.1542103011
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The chemical structure of bilirubin is a symmetrical tetrapyrrole and the two pyrromethenones with two carboxyethyl groups at C-8 and C-12, are syn-periplanar, i.e. Z-configuration of carbon-carbon double bounds at C-4, C-15 as in a partially opened book, and the angle between the planes about 97°. The bilirubin is reversibly bound by human serum albumin because of its hydrophobic nature, and distributed to biological membranes in various tissues. The bilirubin metabolism consists of production, distribution, hepatic uptake, conjugation, excretion, enterohepatic circulation, photoisomerization and oxidization. Serum total bilirubin receives all those influences. At present, serum bilirubin analysis by HPLC is the gold standard.

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