雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Platelet-activating factor acetylhydrolase Kei Satoh 1 1Hirosaki University Graduate School of Medicine and School of Medicine Keyword: 血小板活性化因子アセチルヒドロラーゼ , リポ蛋白質関連ホスホリパーゼA2(lipoprotein-associated phospholipase A2) , 動脈硬化 , 炎症 pp.151-156
Published Date 2012/2/15
DOI https://doi.org/10.11477/mf.1542102915
  • Abstract
  • Look Inside
  • Reference

Platelet-activating factor acetylhydrolase (PAF-AH) inactivates PAF by the removal of its sn-2 acetyl group, and the enzyme in plasma is bound to lipoproteins. Plasma PAF-AH activity is enhanced in various conditions including disorders of lipid metabolism, atherosclerotic diseases, and inflammatory diseases, which has been considered as an adaptation to these abnormalities. Recently, however, increased plasma PAF-AH is also regarded as a risk for coronary heart disease ; and an enzyme inhibitor is under evaluation for its effectiveness in the disease prevention in an ongoing phase Ⅲ clinical trial. Plasma PAF-AH deficiency, found in Asian populations but not in Caucasians, has been suggested to serve as a genetic risk factor for these diseases, but one recent study suggests the deficiency might be protective for the occurrence of ischemic heart disease. Thus the clinical implications of plasma PAF-AH activity are still controversial and may be unraveled by future studies.


Copyright © 2012, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

関連文献

もっと見る

文献を共有