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Recent advance in pathogenesis of Guillain-Barré syndrome Tomoko Komagamine 1 , Nobuhiro Yuki 2 1Department of Neurology, Dokkyo Medical University 2Departments of Microbiology and Medicine, National University of Singapore Keyword: Guillain-Barré症候群 , 分子相同性 , ガングリオシド pp.1249-1257
Published Date 2011/10/30
DOI https://doi.org/10.11477/mf.1542102810
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Guillain-Barré syndrome, the most frequent manifestation of which is acute progressive limb weakness, is the first verification of the causative mechanism of molecular mimicry in autoimmune diseases. IgG antibodies against gangliosides are found in patients with Guillain-Barré syndrome, following Campylobacter jejuni enteritis. Carbohydrate mimicry was identified between human GM1 ganglioside and the lipo-oligosaccharide of C. jejuni from the patients. Guillain-Barré syndrome experimental rabbits and mice revealed the mechanism of the induction of pathogenic antibodies against gangliosides. Understanding of this pathogenesis is helpful in the reclassification of the nosologic positions of Guillain-Barré syndrome and its subtypes.


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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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