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糖尿病患者では,感染症が発症・重症化しやすく,健常者に比し死亡率も高い.高血糖状態では白血球機能の障害,特に遊走能・走化性,貪食能,殺菌能の低下をきたすことがこれまでに報告されている.血行障害や神経障害なども易感染性に寄与しており,合併症の進行した糖尿病患者では特に留意する必要がある.高血糖により低下した白血球機能は血糖の是正により改善することが報告されており,感染症の発症・増悪を防ぐためには良好な血糖コントロールが必要である.
It is commonly recognized that the incidence of infection is higher in persons with diabetes mellitus and that such infections result in death more frequently compared with healthy individuals. Leukocyte dysfunction, particularly, chemotaxis, phagocytosis and bactericidal activity have been described previously. Susceptibility to infection in diabetic patients correlates with leukocyte dysfunction and diabetic complications including vascular insufficiency and neuropathy. Several reports suggest that good control of blood glucose levels can prevent the incidence of infection in diabetic patients.
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