Genes and polymorphisms responsible for the development of diabetes mellitus Naoko Iwasaki 1 1Tokyo Women's Medical University. The Diabetes Center Keyword: 遺伝子変異 , 感受性多型 , 遺伝子診断 , 生命倫理 pp.987-997
Published Date 2010/9/15
DOI https://doi.org/10.11477/mf.1542102381
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We have had a significant advantage during recent two decades in identifying the causative mutations and susceptible polymorphisms in genes responsible for the development of diabetes. These include MODY genes, mutations in mitochondrial diabetes, type 1 and type 2 diabetes mellitus. Such progress has given us a better understanding of the disease mechanisms, new treatment targets and genetic diagnosis. We reviewed the clinical characteristics and associated mutations/polymorphisms for each type of diabetes including the advantages and ethical issues in applying the genetic test in clinical settings.

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