モノクローナル抗体にて検索した進行性鼻壊疽の1例

A Case of Progressive Necrotiziag Rhinitis Studied by Monoclonal Antibodies

I．緒言

　いわゆる進行性鼻壊疽は最近の免疫組織学的手法などの進歩に伴い，若干の分類の修正が必要とされてきている^1,2）。今回我々は病理組織学的にpolymorphic reticulosisと診断された症例の鼻腔組織を免疫組織学的にハイブリドーマ由来モノクローナル抗体にて検索したところ，LeuシリーズにてT-cell lymphomaとみなされた症例を経験したので若干の文献的考察を加えて報告する。

　Polymorphic reticulosis (lymphoma mid granulomatosis) of the nasal cavity was studied by frozen section immunohistochemistry using monoclonal antibodies (anti-Len 4, anti-Len 2a, anti-Lett 3a) to evaluate the expression of lymphocyte differentiation antigens by the proliferating cells.

　Most of atypical lymphoid cells in this case revealed positive reactions to anti-Len 4, anti-Leu 2a, anti-Leu 3a (thymic-T cell nature). Based on these immunological findings, polymorphic reticulosis in the present case was regarded as T cell lymphoma.

　We thus postulated that some of progressive necrotizing rhinitis might correspond to malignant lymphoma, and for diagnosis of this disease immunological study is essential.