トロトラスト沈着症

THORIUM-DIOXIDE GRANULOMA

　I．はじめに

　トロトラスト（Thorotrast）は1928年にドイツで生まれた血管造影剤で，翌29年（昭和3年）にRadt, P. の論文^1）によつて世界中に紹介された。

　この新しいX線診断用の造影剤は化学的には二酸化トリウムの膠質溶液（Thorium-dioxideSol）で少量で非常に優れた造影効果を発揮したので，それからおよそ17年間すなわち第二次世界大戦終了まで広く使用されることになつた。

　A case of Vernet's syndrome due to thorium-dioxide (Thorotrast) granuloma of the neck was presented.

　A patient, 65-year-old male, had a history of a machinegun wound in the head since 1939 during World War II. For the purpose of cerebral angiography, Thorotrast was injected into the carotid a rtery on the right side in 1940. In 1960, hoarseness, difficulty swallowing and hypersalivation appeared.

　Physical examination revealed diffuse firm atrophy of the right neck muscles, the paralyzed right vocal cord and hemiglossoplegia. The soft palate was immobilized on the same side.

　An x-ray film of the neck demonstrated an irregular density extending from the base of the skull to the right clavicle. These findings suggested the accidental extravasation of Thorotrast at the time of carotid angiography.