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人工放射型同位元素が1935年Hevesyによつて始めてトレーサーとして使用されてより,種々の医学的研究が行はれで来て居る。その中の一つとして悪性腫瘍に対するオートラヂオグラフ(以下A.R.G.と略す)の応用がある。即ちA.R.G.は悪性腫瘍の個体に体外的或は体内的にアイソトープを与え,之のアイソトープが悪型腫瘍組織に他組織より,より余計に親和型を有する性質を利用して,このP32の集れる悪性腫瘍組織上にフイルムを固定し,このフィルムにP32の放射による影像の如何を求むる方法である。
我々は以前からP32を種の実験的研究に応用して居るが,上記の趣旨により今回は上顎癌の患者に之を用ひ認むべき成績を得たので此処に報告する次第である。
Takahashi and associates report the results on use of isotope P32 in making diagnosis of malignancy in the field of otolaryngology. Ten cases employed as material of this study consi-sted of 6 cases of maxillary cancer, 1 case of laryngeal cancer and three other cases that in-cluded each of maxillary sinusitis, ideopathic tracheal hemorrhage, and chronic granuloma of malar region, the all of which the diagnosis have been established previously. The P32 is injected intravenously in dosage of 8.4 to 14 microcuri per kilogram body weight. And there-afterfollowing this injection a small dental X-Ray films is pasted on to the area under observation for auto-exposure. The results are as follows:
The X-ray films showed positiye exposure in three cases of maxillary cancer, 1 of laryngeal cancer and in 1 of chronic granuloma. In three remaining cases of maxillary cancer in which the film exposure turned out to be negative, the cancerous condition in 2 had bad been era-dicated by previous operation while, in the third the amount of P32 used seemed to have been inadequate to porduce the desire effect. In all other cases the results proved to be negative.
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